About Enhancer
| Enhancer ID: | E_01342 |
| Species: | Homo sapiens |
| Position : | chr8:118250000-118252000   |
| Year: | 2024 |
| Title: | Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic ζ±-cell survival and function. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38661000 |
| Tissue: | islet of Langerhans |
| Tissue Ontology ID: | UBERON:0000006 |
| Cell Source: | BRE |
| CVCL ID: | CVCL_A5NF |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; Hi-C; eQTL analysis |
| Low Throughput Method: | CRISPR Knockout; Luciferase Reporter Assay; ChIP-RT-qPCR; RT-RT-qPCR; Western blot; CRISPR-Cas9 |
About Target Gene
| Target gene : | SLC30A8 |
About TF
| TF name : | PDX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PDX1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| PDX1 | Regulation of gene expression in beta cells | reactome | 17 |
| PDX1 | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| PDX1 | Type II diabetes mellitus | kegg | 44 |
| PDX1 | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer