About Enhancer
| Enhancer ID: | E_01340 |
| Species: | Homo sapiens |
| Position : | chr19:51352371-51354471   |
| Year: | 2014 |
| Title: | Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 24778216 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LNCaP |
| CVCL ID: | CVCL_0395 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer RNA assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | AR/H3K27ac/H3K4me1 ChIP-seq data integration; GRO-seq data integration |
| Low Throughput Method: | DHT treatment; KLK3e RNAi; RT-qPCR; AR/MED1 RIP-qPCR; ChIP-qPCR; 3C/3C-qPCR; orientation-dependent and ARE III deletion luciferase reporter assays |
About Target Gene
| Target gene : | KLK2 |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01430 | chr19:51352419-51358208 | prostate gland | malignant cell | prostate cancer |
| E_01431 | chr19:51352419-51358208 | prostate gland | malignant cell | prostate cancer |
| E_04667 | chr19:51353370-51354238 | prostate gland | malignant cell | prostate cancer |
| E_04872 | chr19:51353600-51354200 | prostate gland | malignant cell | prostate cancer |
Expression of Target Genes for the Enhancer