About Enhancer
| Enhancer ID: | E_01334 |
| Species: | Homo sapiens |
| Position : | chr1:3593076-3594185   |
| Year: | 2022 |
| Title: | Requirement for TP73 and genetic alterations originating from its intragenic super-enhancer in adult T-cell leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | adult T-cell leukemia/lymphoma |
| PMID: | 35908104 |
| MONDO: | MONDO:0019471 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | TL-Om1 |
| CVCL ID: | CVCL_B473 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Super-enhancer constituent activity assay; TF binding assay; Enhancer-promoter interaction assay; Functional enhancer perturbation assay; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; IRF4 ChIP-seq; RELA ChIP-seq; H3K27ac HiChIP; RNA-seq |
| Low Throughput Method: | CRISPR/Cas9 enhancer excision; dCas9-KRAB CRISPRi; RT-qPCR; Western blot; In vivo phenotyping |
About Target Gene
| Target gene : | TP73 |
About TF
| TF name : | IRF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF4 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| IRF4 | IL4-mediated signaling events | pid | 66 |
| IRF4 | Interferon alpha/beta signaling | reactome | 67 |
| IRF4 | Interferon gamma signaling | reactome | 88 |
| IRF4 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01335 | chr1:3593076-3594185 | blood | T cell | adult T-cell leukemia/lymphoma |
Expression of Target Genes for the Enhancer