About Enhancer
| Enhancer ID: | E_01301 |
| Species: | Homo sapiens |
| Position : | chr1:116544766-116545360   |
| Year: | 2022 |
| Title: | PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 36516256 |
| MONDO: | MONDO:0004947 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | primary B-ALL blasts |
| Cell Type: | B-lineage lymphoblast |
| Experiment Type: | Endogenous TF-site perturbation; enhancer reporter validation; immunotherapy-response functional analysis |
| High Throughput Method: | genome-wide CRISPR screen; RNA-seq; ChIP-seq/epigenomic profiling |
| Low Throughput Method: | PAX5-motif CRISPR editing; luciferase reporter assay; flow cytometry; CD58 expression assay; T-cell activation and blinatumomab cytotoxicity assays |
About Target Gene
| Target gene : | CD58 |
About TF
| TF name : | PAX5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX5 | C-MYB transcription factor network | pid | 87 |
| PAX5 | ID | netpath | 38 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01238 | chr1:116544766-116545360 | bone marrow | B-lineage lymphoblast/leukemia cell | B-cell acute lymphoblastic leukemia |
| E_01239 | chr1:116544766-116545360 | blood | B-lineage lymphoblast/leukemia cell | B-cell acute lymphoblastic leukemia |
| E_01277 | chr1:116544766-116545360 | blood | B-lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01279 | chr1:116544766-116545360 | bone marrow | B-lineage lymphoblast/leukemia cell | B-cell acute lymphoblastic leukemia |
| E_01280 | chr1:116544766-116545360 | blood | B-lineage lymphoblast/leukemia cell | B-cell acute lymphoblastic leukemia |
| E_01302 | chr1:116544766-116545360 | blood | B-lineage lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01312 | chr1:116544766-116545360 | bone marrow | B-lineage lymphoblast | B-cell acute lymphoblastic leukemia |
| E_01313 | chr1:116544766-116545360 | blood | B-lineage lymphoblast | B-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer