About Enhancer
| Enhancer ID: | E_01175 |
| Species: | Homo sapiens |
| Position : | chr16:68362000-68362400   |
| Year: | 2022 |
| Title: | An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 35264579 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | hepatocellular carcinoma cell model |
| Cell Type: | hepatocellular carcinoma cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Enhancer activity assay; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPR Knockout, CRISPRi, CRISPRa, qRT-PCR, Western blot, EMSA; Luciferase reporter assay; Allele-specific reporter assay; In vivo phenotyping |
About Target Gene
| Target gene : | PRMT7 |
About TF
| TF name : | HNF4A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HNF4A | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| HNF4A | HIF-1-alpha transcription factor network | pid | 67 |
| HNF4A | Nuclear Receptor transcription pathway | reactome | 51 |
| HNF4A | Regulation of gene expression in beta cells | reactome | 17 |
| HNF4A | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| HNF4A | TGF_beta_Receptor | netpath | 220 |
| HNF4A | Maturity onset diabetes of the young | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer