About Enhancer
| Enhancer ID: | E_01169 |
| Species: | Homo sapiens |
| Position : | chr20:52157000-52158500   |
| Year: | 2010 |
| Title: | A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Kaposi's sarcoma |
| PMID: | 20236932 |
| MONDO: | MONDO:0005055 |
| Tissue: | zone of skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | JOV675 |
| CVCL ID: | CVCL_8250 |
| Cell Type: | Kaposi sarcoma cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq; ChIP-chip; RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; RT-RT-qPCR, 3C |
About Target Gene
| Target gene : | CYP24A1 |
About TF
| TF name : | VDR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| VDR | Direct p53 effectors | pid | 141 |
| VDR | Nuclear Receptor transcription pathway | reactome | 51 |
| VDR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| VDR | Retinoic acid receptors-mediated signaling | pid | 30 |
| VDR | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| VDR | TGF_beta_Receptor | netpath | 220 |
| VDR | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| VDR | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| VDR | Vitamin D metabolism and pathway | panther | 6 |
| VDR | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer