About Enhancer
| Enhancer ID: | E_01161 |
| Species: | Homo sapiens |
| Position : | chr17:32565596-32566796   |
| Year: | 2011 |
| Title: | An evolutionarily conserved TNF-alpha-responsive enhancer in the far upstream region of human CCL2 locus influences its gene expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 21551367 |
| Cell Source: | U-87MG |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; In vivo functional validation |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | CCL2 |
About TF
| TF name : | CEBPB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPB | C-MYB transcription factor network | pid | 87 |
| CEBPB | EGFR1 | netpath | 475 |
| CEBPB | FOXA1 transcription factor network | pid | 45 |
| CEBPB | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPB | IFN-gamma pathway | pid | 43 |
| CEBPB | IL3-mediated signaling events | pid | 27 |
| CEBPB | IL4-mediated signaling events | pid | 66 |
| CEBPB | IL4 | netpath | 75 |
| CEBPB | IL6-mediated signaling events | pid | 48 |
| CEBPB | IL6 | netpath | 85 |
| CEBPB | RANKL | netpath | 84 |
| CEBPB | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| CEBPB | Regulation of retinoblastoma protein | pid | 67 |
| CEBPB | Senescence-Associated Secretory Phenotype (SASP) | reactome | 108 |
| CEBPB | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| CEBPB | TCR | netpath | 261 |
| CEBPB | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPB | Validated nuclear estrogen receptor alpha network | pid | 65 |
| CEBPB | Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 | wikipathways | 62 |
| CEBPB | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| CEBPB | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
| CEBPB | Hs_Lung_fibrosis_WP3624_91475 | wikipathways | 23 |
| CEBPB | Hs_IL17_signaling_pathway_WP2112_89838 | wikipathways | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
Expression of Target Genes for the Enhancer