About Enhancer
| Enhancer ID: | E_01155 |
| Species: | Homo sapiens |
| Position : | chr20:52173000-52174500   |
| Year: | 2010 |
| Title: | A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20236932 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | LS180 |
| CVCL ID: | CVCL_0397 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay; Enhancer activity assay; Endogenous enhancer perturbation; TF binding assay; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | ChIP-seq, ChIP-chip, RNA-seq; ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, 3C; Luciferase reporter assay; ChIP; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | CYP24A1 |
About TF
| TF name : | VDR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| VDR | Direct p53 effectors | pid | 141 |
| VDR | Nuclear Receptor transcription pathway | reactome | 51 |
| VDR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| VDR | Retinoic acid receptors-mediated signaling | pid | 30 |
| VDR | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| VDR | TGF_beta_Receptor | netpath | 220 |
| VDR | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| VDR | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| VDR | Vitamin D metabolism and pathway | panther | 6 |
| VDR | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer