About Enhancer
| Enhancer ID: | E_01154 |
| Species: | Homo sapiens |
| Position : | chr2:217918268-217921910   |
| Year: | 2014 |
| Title: | Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast Cancer |
| PMID: | 25248036 |
| MONDO: | MONDO:0007254 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | Breast Cancer Cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Genetic-variant functional analysis; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | IGFBP5 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01172 | chr2:217920100-217921400 | zone of skin | melanoma cell | cutaneous melanoma |
Expression of Target Genes for the Enhancer