About Enhancer
| Enhancer ID: | E_01147 |
| Species: | Homo sapiens |
| Position : | chr3:98678906-98697335   |
| Year: | 2025 |
| Title: | A novel super-enhancer-driven lncRNA LINC00973 governs head and neck squamous cell carcinoma progression through EN2. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | head and neck squamous cell carcinoma |
| PMID: | 41419462 |
| MONDO: | MONDO:0010150 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Hep-G2 |
| CVCL ID: | CVCL_0027 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay; Endogenous enhancer perturbation; TF binding assay; Chromatin interaction assay; Chromatin-state profiling; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C, ATAC-seq; H3K27ac HiChIP; HiChIP |
| Low Throughput Method: | ChIP-RT-qPCR, CRISPRi, Luciferase Reporter Assay, qRT-PCR, Western blot, co-IP; CRISPRi; In vivo phenotyping |
About Target Gene
| Target gene : | LINC00973 |
About TF
| TF name : | FOSL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL1 | AP-1 transcription factor network | pid | 71 |
| FOSL1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| FOSL1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| FOSL1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL1 | TGF-beta signaling pathway | panther | 88 |
| FOSL1 | Validated targets of C-MYC transcriptional activation | pid | 80 |
| FOSL1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL1 | Wnt signaling pathway | kegg | 135 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer