About Enhancer
| Enhancer ID: | E_01131 |
| Species: | Homo sapiens |
| Position : | chr8:98310330-98314427   |
| Year: | 2017 |
| Title: | A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Small B Cell Lymphoma |
| PMID: | 29045844 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Mantle Cell Lymphoma (MCL) |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; 4C-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | MYBL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYBL2 | E2F transcription factor network | pid | 77 |
| MYBL2 | G0 and Early G1 | reactome | 25 |
| MYBL2 | Polo-like kinase mediated events | reactome | 16 |
| MYBL2 | Hs_Gastric_Cancer_Network_1_WP2361_86831 | wikipathways | 26 |
| MYBL2 | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01130 | chr8:98310330-98314427 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
| E_01132 | chr8:98310330-98314427 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
| E_01133 | chr8:98310330-98314427 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
Expression of Target Genes for the Enhancer