About Enhancer
| Enhancer ID: | E_01126 |
| Species: | Homo sapiens |
| Position : | chr8:98253530-98257713   |
| Year: | 2017 |
| Title: | A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Small B Cell Lymphoma |
| PMID: | 29045844 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Mantle Cell Lymphoma (MCL) |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; 4C-seq |
| Low Throughput Method: | ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | IRF8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF8 | GMCSF-mediated signaling events | pid | 38 |
| IRF8 | Interferon alpha/beta signaling | reactome | 67 |
| IRF8 | Interferon gamma signaling | reactome | 88 |
| IRF8 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| IRF8 | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01127 | chr8:98253530-98257713 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
| E_01128 | chr8:98253530-98257713 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
| E_01129 | chr8:98253530-98257713 | blood / hematopoietic system | B cell | Small B Cell Lymphoma |
Expression of Target Genes for the Enhancer