About Enhancer
| Enhancer ID: | E_01117 |
| Species: | Homo sapiens |
| Position : | chr4:122458532-122459022   |
| Year: | 2025 |
| Title: | Bidirectional epigenetic editing reveals hierarchies in gene regulation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38760566 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat E6.1 |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Chromatin accessibility assay; Enhancer-promoter regulatory interaction analysis; Endogenous enhancer perturbation; Disease-variant functional analysis |
| High Throughput Method: | Pooled bidirectional CRISPRai gRNA enrichment sequencing; ATAC-seq; public histone ChIP-seq; ABC-model enhancer-promoter contact analysis using public Hi-C; published enhancer-interaction data; single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | CRISPRa; CRISPRi; intracellular IL2 flow cytometry; ATAC-qPCR |
About Target Gene
| Target gene : | IL2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01097 | chr4:122458532-122459022 | blood | CD4-positive, alpha-beta memory T cell | NA |
Expression of Target Genes for the Enhancer