About Enhancer
| Enhancer ID: | E_01107 |
| Species: | Homo sapiens |
| Position : | chr20:48900221-48901229   |
| Year: | 2019 |
| Title: | Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 30659195 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Human hepatocellular carcinoma cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | MBDCap-seq, WGBS, ChIP-seq, RNA-seq, Hi-C; whole-genome sequencing |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, Bisulfite pyrosequencing; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | CEBPB |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02876 | chr20:48400000-49200000 | breast | malignant cell | breast cancer |
| E_02877 | chr20:48400000-49200000 | breast | malignant cell | breast cancer |
| E_01098 | chr20:48900221-48901229 | liver | hepatoblast | hepatocellular carcinoma |
| E_01105 | chr20:48900221-48901229 | liver | NA | hepatocellular carcinoma |
| E_01106 | chr20:48900221-48901229 | liver | NA | hepatocellular carcinoma |
| E_01108 | chr20:48900221-48901229 | liver | hepatocyte | hepatocellular carcinoma |
| E_01115 | chr20:48900221-48901229 | liver | NA | hepatocellular carcinoma |
| E_01116 | chr20:48900221-48901229 | liver | NA | hepatocellular carcinoma |
| E_01143 | chr20:48900221-48901229 | uterine cervix | NA | hepatocellular carcinoma |
| E_01145 | chr20:48900221-48901229 | liver | NA | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer