About Enhancer
| Enhancer ID: | E_01085 |
| Species: | Homo sapiens |
| Position : | chr21:36399106-36399322   |
| Year: | 2019 |
| Title: | RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 31023702 |
| MONDO: | MONDO:0018874 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary RUNX1-mutant AML |
| Cell Type: | myeloid leukemia cell |
| Experiment Type: | Endogenous enhancer editing; AML survival dependency |
| High Throughput Method: | H3K27ac/BRD4 chromatin profiling; transcriptomic profiling |
| Low Throughput Method: | CRISPR-Cas9 eR1 editing/deletion; RT-qPCR; immunoblotting; proliferation; apoptosis; colony-forming assays |
About Target Gene
| Target gene : | RUNX1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01075 | chr21:36399106-36399322 | bone marrow | AML cell | acute myeloid leukemia |
| E_01080 | chr21:36399106-36399322 | bone marrow | AML cell | acute myeloid leukemia |
| E_01084 | chr21:36399106-36399322 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01086 | chr21:36399106-36399322 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01087 | chr21:36399106-36399322 | blood | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer