About Enhancer
| Enhancer ID: | E_01078 |
| Species: | Homo sapiens |
| Position : | chr13:74002153-74004429   |
| Year: | 2018 |
| Title: | Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | head and neck squamous cell carcinoma |
| PMID: | 28963353 |
| MONDO: | MONDO:0010150 |
| Tissue: | head and neck epithelium |
| Cell Source: | BICR31 squamous carcinoma cells |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Cancer super-enhancer mapping; enhancer-promoter interaction; constituent CRISPRi |
| High Throughput Method: | Whole-genome/copy-number profiling; p300/H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | KRAB-dCas9 CRISPRi; 3C; luciferase reporter; RT-qPCR; proliferation assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | KLF5 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00944 | chr13:73880413-74042621 | lung | malignant cell | lung adenocarcinoma |
| E_00945 | chr13:73880413-74042621 | lung | malignant cell | lung adenocarcinoma |
| E_01079 | chr13:73941969-74004429 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_01331 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01332 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01333 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01408 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer