About Enhancer
| Enhancer ID: | E_01075 |
| Species: | Homo sapiens |
| Position : | chr21:36399106-36399322   |
| Year: | 2019 |
| Title: | RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 31023702 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | primary RUNX1-mutant AML |
| Cell Type: | AML cell |
| Experiment Type: | Endogenous enhancer editing; enhancer dependency; leukemia survival analysis |
| High Throughput Method: | ChIP-seq; H3K27ac profiling; RNA-seq; Hi-C data integration |
| Low Throughput Method: | CRISPR/Cas9 eR1 editing-out; qRT-PCR; western blot; proliferation assay; apoptosis assay; colony-forming assay |
About Target Gene
| Target gene : | RUNX1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01080 | chr21:36399106-36399322 | bone marrow | AML cell | acute myeloid leukemia |
| E_01084 | chr21:36399106-36399322 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01085 | chr21:36399106-36399322 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01086 | chr21:36399106-36399322 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01087 | chr21:36399106-36399322 | blood | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer