About Enhancer
| Enhancer ID: | E_01074 |
| Species: | Homo sapiens |
| Position : | chr21:43795658-43798708   |
| Year: | 2021 |
| Title: | Enhancer release and retargeting activates disease-susceptibility genes. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 34040254 |
| MONDO: | MONDO:0004989 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; TF binding assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | GRO-seq; ChIA-PET; ChIP-seq; pooled CRISPRi screen; GWAS |
| Low Throughput Method: | CRISPR/Cas9 enhancer deletion; 4C-seq; qRT-PCR; ChIP-qPCR; CRISPRi; Site-directed/motif mutagenesis |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer