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Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_01054
Species: Homo sapiens
Position : chr17:79780000-79828000
Year: 2022
Title: Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-汕/SMAD3 pathway.
Genome Build: hg19
Enhancer Type: Enhancer
Condition: Disease
Disease Name: lung adenocarcinoma
PMID:  35982471
MONDO: MONDO:0005061
Tissue: lung
Tissue Ontology ID: UBERON:0002048
Cell Source: PC-9
CVCL ID: CVCL_B260
Cell Type: malignant cell
Cell Ontology ID: CL:0001064
Experiment Type: Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Enhancer activity assay; TF binding assay; Chromatin interaction assay; Chromatin-state profiling; In vivo functional validation
High Throughput Method: ChIP-seq, Hi-C, RNA-seq; ChIP-seq; Hi-C
Low Throughput Method: Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot; Luciferase reporter assay; ChIP; In vivo phenotyping; Reporter assay
About Target Gene
Target gene : LINC01977
About TF
TF name : CREBBP
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
CREBBP Activation of anterior HOX genes in hindbrain development during early embryogenesis reactome 120
CREBBP Activation of gene expression by SREBF (SREBP) reactome 42
CREBBP AndrogenReceptor netpath 167
CREBBP Attenuation phase reactome 28
CREBBP BMAL1:CLOCK,NPAS2 activates circadian gene expression reactome 42
CREBBP BMP signaling in Drosophila ( BMP signaling in Drosophila ) inoh 7
CREBBP BMP signaling in Drosophila (dorsal midline) ( BMP signaling in Drosophila ) inoh 7
CREBBP BMP signaling in Drosophila (dorsolateral) ( BMP signaling in Drosophila ) inoh 7
CREBBP BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 34
CREBBP BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 13
CREBBP C-MYB transcription factor network pid 87
CREBBP C. elegans Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 8
CREBBP Canonical Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 19
CREBBP CD209 (DC-SIGN) signaling reactome 21
CREBBP Circadian Clock reactome 49
CREBBP Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants reactome 57
CREBBP Constitutive Signaling by NOTCH1 PEST Domain Mutants reactome 57
CREBBP Direct p53 effectors pid 141
CREBBP E2F transcription factor network pid 77
CREBBP Factors involved in megakaryocyte development and platelet production reactome 111
CREBBP Formation of the beta-catenin:TCF transactivating complex reactome 88
CREBBP FOXA1 transcription factor network pid 45
CREBBP FOXM1 transcription factor network pid 43
CREBBP FoxO family signaling pid 50
CREBBP Glucocorticoid receptor regulatory network pid 85
CREBBP HATs acetylate histones reactome 142
CREBBP Hedgehog netpath 39
CREBBP Hedgehog signaling events mediated by Gli proteins pid 49
CREBBP Hedgehog signaling pathway panther 19
CREBBP Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway panther 126
CREBBP HIF-1-alpha transcription factor network pid 67
CREBBP HIF-2-alpha transcription factor network pid 34
CREBBP Huntington disease panther 113
CREBBP Hypoxia response via HIF activation panther 16
CREBBP IFN-gamma pathway pid 43
CREBBP IL12 signaling mediated by STAT4 pid 33
CREBBP IL4 netpath 75
CREBBP IL6 netpath 85
CREBBP LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) inoh 10
CREBBP LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production reactome 5
CREBBP Mammalian Notch signaling pathway ( Notch signaling pathway Diagram ) inoh 15
CREBBP NICD traffics to nucleus reactome 13
CREBBP Notch-HLH transcription pathway reactome 13
CREBBP Notch-mediated HES/HEY network pid 48
CREBBP NOTCH1 Intracellular Domain Regulates Transcription reactome 47
CREBBP p53 pathway panther 39
CREBBP p53 pathway pid 59
CREBBP Posttranslational regulation of adherens junction stability and dissassembly pid 50
CREBBP PPARA activates gene expression reactome 113
CREBBP Pre-NOTCH Transcription and Translation reactome 29
CREBBP Presenilin action in Notch and Wnt signaling pid 46
CREBBP Prolactin netpath 105
CREBBP Regulation of Androgen receptor activity pid 54
CREBBP Regulation of gene expression by Hypoxia-inducible Factor reactome 10
CREBBP Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) reactome 20
CREBBP Regulation of nuclear SMAD2/3 signaling pid 82
CREBBP Regulation of retinoblastoma protein pid 67
CREBBP Retinoic acid receptors-mediated signaling pid 30
CREBBP Role of Calcineurin-dependent NFAT signaling in lymphocytes pid 54
CREBBP RORA activates gene expression reactome 27
CREBBP Signaling events mediated by HDAC Class I pid 89
CREBBP Signaling events mediated by HDAC Class III pid 41
CREBBP Signaling events mediated by Stem cell factor receptor (c-Kit) pid 53
CREBBP Signaling events mediated by TCPTP pid 40
CREBBP Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
CREBBP Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
CREBBP TCR netpath 261
CREBBP TGF-beta signaling pathway panther 88
CREBBP TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) inoh 51
CREBBP TGF_beta_Receptor netpath 220
CREBBP TNFalpha netpath 274
CREBBP TP53 Regulates Transcription of Genes Involved in Cytochrome C Release reactome 19
CREBBP TRAF3-dependent IRF activation pathway reactome 14
CREBBP TRAF6 mediated IRF7 activation reactome 33
CREBBP Transcription regulation by bZIP transcription factor panther 42
CREBBP Transcriptional activation of mitochondrial biogenesis reactome 43
CREBBP Transcriptional regulation of white adipocyte differentiation reactome 79
CREBBP Validated targets of C-MYC transcriptional activation pid 80
CREBBP Wnt signaling pathway panther 250
CREBBP YAP1- and WWTR1 (TAZ)-stimulated gene expression reactome 29
CREBBP Cell cycle kegg 124
CREBBP Wnt signaling pathway kegg 135
CREBBP Notch signaling pathway kegg 44
CREBBP TGF-beta signaling pathway kegg 82
CREBBP Adherens junction kegg 70
CREBBP Jak-STAT signaling pathway kegg 149
CREBBP Long-term potentiation kegg 67
CREBBP Melanogenesis kegg 100
CREBBP Huntington's disease kegg 182
CREBBP Pathways in cancer kegg 321
CREBBP Renal cell carcinoma kegg 65
CREBBP Prostate cancer kegg 85
CREBBP Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27
CREBBP Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 wikipathways 12
Enhancer Associated Network
Overlapping Enhancers (hg19) 1 found
Enhancer ID Position Tissue Cell Disease
E_01055 chr17:79780000-79828000 lung malignant cell lung adenocarcinoma
Expression of Target Genes for the Enhancer