About Enhancer
| Enhancer ID: | E_01027 |
| Species: | Homo sapiens |
| Position : | chr4:75700000-76000000   |
| Year: | 2019 |
| Title: | The SNP of rs6854845 suppresses transcription via the DNA looping structure alteration of super-enhancer in colon cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 31078271 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Human normal colon epithelial cell |
| Cell Type: | colon epithelial cell |
| Cell Ontology ID: | CL:0011108 |
| Experiment Type: | Chromatin interaction assay, Functional perturbation assay, Enhancer activity assay; Endogenous enhancer perturbation; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | Hi-C, RNA-seq; GWAS |
| Low Throughput Method: | CRISPR knockout, 3C, ChIP-RT-qPCR, RT-RT-qPCR; CRISPR-Cas9 endogenous deletion/editing; 3C; RT-qPCR |
About Target Gene
| Target gene : | EREG |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00966 | chr4:75700000-76000000 | colon | colon epithelial cell | colorectal cancer |
| E_01011 | chr4:75700000-76000000 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_01024 | chr4:75700000-76000000 | colon | colon epithelial cell | colorectal cancer |
| E_01031 | chr4:75700000-76000000 | colon | colon epithelial cell | colorectal cancer |
| E_01012 | chr4:75746565-75746914 | colon | colon epithelial cell | colorectal cancer |
| E_01013 | chr4:75746565-75746914 | colon | colon epithelial cell | colorectal cancer |
Expression of Target Genes for the Enhancer