About Enhancer
| Enhancer ID: | E_00975 |
| Species: | Homo sapiens |
| Position : | chr8:129166547-129190290   |
| Year: | 2016 |
| Title: | Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 26656844 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Human non-small cell lung carcinoma cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Epigenomic mapping, Enhancer functional validation, Genome editing; Endogenous enhancer perturbation |
| High Throughput Method: | GISTIC copy number analysis, H3K27ac ChIP-seq, p300 ChIP-seq, DNase-seq, RNA-seq, NFE2L2 ChIP-seq, CEBPB ChIP-seq, Gene set enrichment analysis |
| Low Throughput Method: | Luciferase reporter assay, CRISPR-Cas9 enhancer deletion, CRISPR dCas9 KRAB repression, Chromosome conformation capture RT-qPCR, siRNA knockdown, Clonogenic growth assay, Anchorage independent growth assay, TaqMan RT-qPCR; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NFE2L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2L2 | Protein processing in endoplasmic reticulum | kegg | 166 |
| NFE2L2 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| NFE2L2 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00951 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_00974 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_02502 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_02503 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_02504 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_00949 | chr8:129188417-129189959 | lung | malignant cell | lung adenocarcinoma |
| E_00950 | chr8:129188417-129189959 | lung | malignant cell | lung adenocarcinoma |
| E_01020 | chr8:129188417-129189959 | lymph node | malignant cell | lung adenocarcinoma |
| E_01025 | chr8:129188417-129189959 | lung | club cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer