About Enhancer
| Enhancer ID: | E_00949 |
| Species: | Homo sapiens |
| Position : | chr8:129188417-129189959   |
| Year: | 2016 |
| Title: | Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 26656844 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A-549 |
| CVCL ID: | CVCL_0023 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; TF motif functional assay; Endogenous enhancer perturbation |
| High Throughput Method: | H3K27ac ChIP-seq; p300 ChIP-seq; DNase-seq; CEBPB ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; mini-e3 reporter dissection; site-directed CEBPB motif deletion; CEBPB siRNA knockdown; RT-qPCR; Western blot; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | CEBPB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPB | C-MYB transcription factor network | pid | 87 |
| CEBPB | EGFR1 | netpath | 475 |
| CEBPB | FOXA1 transcription factor network | pid | 45 |
| CEBPB | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPB | IFN-gamma pathway | pid | 43 |
| CEBPB | IL3-mediated signaling events | pid | 27 |
| CEBPB | IL4-mediated signaling events | pid | 66 |
| CEBPB | IL4 | netpath | 75 |
| CEBPB | IL6-mediated signaling events | pid | 48 |
| CEBPB | IL6 | netpath | 85 |
| CEBPB | RANKL | netpath | 84 |
| CEBPB | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| CEBPB | Regulation of retinoblastoma protein | pid | 67 |
| CEBPB | Senescence-Associated Secretory Phenotype (SASP) | reactome | 108 |
| CEBPB | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| CEBPB | TCR | netpath | 261 |
| CEBPB | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPB | Validated nuclear estrogen receptor alpha network | pid | 65 |
| CEBPB | Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 | wikipathways | 62 |
| CEBPB | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| CEBPB | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
| CEBPB | Hs_Lung_fibrosis_WP3624_91475 | wikipathways | 23 |
| CEBPB | Hs_IL17_signaling_pathway_WP2112_89838 | wikipathways | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00951 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_00974 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_00975 | chr8:129166547-129190290 | lung | malignant cell | lung adenocarcinoma |
| E_02502 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_02503 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_02504 | chr8:129180000-129190000 | lymph node | B cell | diffuse large B-cell lymphoma |
| E_00950 | chr8:129188417-129189959 | lung | malignant cell | lung adenocarcinoma |
| E_01020 | chr8:129188417-129189959 | lymph node | malignant cell | lung adenocarcinoma |
| E_01025 | chr8:129188417-129189959 | lung | club cell | lung adenocarcinoma |
Expression of Target Genes for the Enhancer