About Enhancer
| Enhancer ID: | E_00945 |
| Species: | Homo sapiens |
| Position : | chr13:73880413-74042621   |
| Year: | 2016 |
| Title: | Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 26656844 |
| MONDO: | MONDO:0005061 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | Esophageal Carcinoma |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR; RNAi/siRNA/shRNA |
About Target Gene
| Target gene : | KLF5 |
About TF
| TF name : | NFE2L2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFE2L2 | Protein processing in endoplasmic reticulum | kegg | 166 |
| NFE2L2 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 |
| NFE2L2 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
14 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00944 | chr13:73880413-74042621 | lung | malignant cell | lung adenocarcinoma |
| E_00978 | chr13:73880690-73990596 | NA | malignant cell | Esophageal Carcinoma |
| E_01076 | chr13:73941969-73943506 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_01079 | chr13:73941969-74004429 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_00004 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_00005 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_00006 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_00007 | chr13:73958961-73960160 | colon | malignant cell | colorectal adenocarcinoma |
| E_01077 | chr13:73995211-73996254 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_01078 | chr13:74002153-74004429 | head and neck epithelium | malignant cell | head and neck squamous cell carcinoma |
| E_01331 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01332 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01333 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
| E_01408 | chr13:74003796-74004073 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer