About Enhancer
| Enhancer ID: | E_00941 |
| Species: | Homo sapiens |
| Position : | chr5:51773619-51857504   |
| Year: | 2014 |
| Title: | Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Type 2 Diabetes Mellitus |
| PMID: | 24413736 |
| MONDO: | MONDO:0005148 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | HEK-293,ζ±-Cell |
| CVCL ID: | CVCL_0045 |
| Cell Type: | pancreatic beta cell |
| Cell Ontology ID: | CL:0000169 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Genetic-variant functional analysis; In vivo functional validation; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; EMSA/gel-shift assay; 4C |
About Target Gene
| Target gene : | ISL1 |
About TF
| TF name : | MAFB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MAFB | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| MAFB | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer