About Enhancer
| Enhancer ID: | E_00938 |
| Species: | Homo sapiens |
| Position : | chr4:76213678-76224314   |
| Year: | 2019 |
| Title: | The SNP of rs6854845 suppresses transcription via the DNA looping structure alteration of super-enhancer in colon cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | colon cancer susceptibility / colorectal carcinoma |
| PMID: | 31078271 |
| MONDO: | MONDO:0002032 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | CCD-1108Sk |
| CVCL ID: | CVCL_2352 |
| Cell Type: | colon epithelial cell |
| Cell Ontology ID: | CL:0011108 |
| Experiment Type: | GWAS-variant genome editing; super-enhancer looping; target-gene expression |
| High Throughput Method: | Hi-C/chromatin-state integration; ChIP-seq where reported; 3C |
| Low Throughput Method: | CRISPR/Cas9 rs6854845 editing; 3C; ChIP-qPCR; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | EPGN |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00954 | chr4:76192040-76237727 | colon | NA | colon cancer susceptibility / colorectal carcinoma |
| E_00979 | chr4:76192040-76237727 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_01026 | chr4:76192040-76237727 | lung | colon epithelial cell | colorectal cancer |
| E_00933 | chr4:76213678-76224314 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_00934 | chr4:76213678-76224314 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_00935 | chr4:76213678-76224314 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_00936 | chr4:76213678-76224314 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_00937 | chr4:76213678-76224314 | colon | colon epithelial cell | colon cancer susceptibility / colorectal carcinoma |
| E_01010 | chr4:76213678-76224314 | prostate gland | colon epithelial cell | colorectal cancer |
Expression of Target Genes for the Enhancer