About Enhancer
| Enhancer ID: | E_00906 |
| Species: | Homo sapiens |
| Position : | chr4:55554102-55554596   |
| Year: | 2018 |
| Title: | AML1/ETO trans-activates c-KIT expression through the long range interaction between promoter and intronic enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 29236325 |
| MONDO: | MONDO:0018874 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Kasumi-1 |
| CVCL ID: | CVCL_0589 |
| Cell Type: | myeloblast |
| Cell Ontology ID: | CL:0000835 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay; Chromatin-state profiling |
| High Throughput Method: | ChIP-seq data analysis; patient expression-cohort analysis; ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; ChIP-qPCR; ChIP-3C-qPCR; siRNA knockdown; RT-qPCR; ChIP; 3C; Reporter assay |
About Target Gene
| Target gene : | KIT |
About TF
| TF name : | RUNX1::RUNX1T1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03312 | chr4:55520000-55580000 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
Expression of Target Genes for the Enhancer