About Enhancer
| Enhancer ID: | E_00904 |
| Species: | Homo sapiens |
| Position : | chr8:128018000-128023000   |
| Year: | 2020 |
| Title: | A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 32680982 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LNCaP clone FGC |
| CVCL ID: | CVCL_1379 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | AR ChIP-seq; FOXA1 ChIP-seq; H3K27ac ChIP-seq; ATAC-seq; DHS; 4C |
| Low Throughput Method: | Allele-specific Luciferase reporter assay; EMSA; SPDEF knockdown; CRISPRi; RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | SPDEF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SPDEF | AndrogenReceptor | netpath | 167 |
| SPDEF | PDGF signaling pathway | panther | 113 |
| SPDEF | Regulation of Androgen receptor activity | pid | 54 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer