About Enhancer
| Enhancer ID: | E_00895 |
| Species: | Homo sapiens |
| Position : | chr2:16619625-16621501   |
| Year: | 2023 |
| Title: | TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 37591943 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary TAL1-positive T-ALL cells |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | TAL1/H3K27ac ChIP-seq; ATAC-seq; 3D-chromatin profiling; RNA-seq |
| Low Throughput Method: | ChIP-qPCR; RT-qPCR; MYCN functional-dependency assays; Xenograft/xenotransplant |
About Target Gene
| Target gene : | MYCN |
About TF
| TF name : | TAL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer