About Enhancer
| Enhancer ID: | E_00878 |
| Species: | Homo sapiens |
| Position : | chr19:29844909-29845562   |
| Year: | 2023 |
| Title: | eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36803948 |
| Tissue: | esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | CP-A |
| CVCL ID: | CVCL_C451 |
| Cell Type: | esophageal epithelial cell |
| Experiment Type: | Enhancer activity; KLF5 binding; functional CRISPRi perturbation |
| High Throughput Method: | Patient RNA-seq; ATAC-seq; KAS-seq; H3K27ac ChIP-seq; KLF5 ChIP-seq; RNA-seq |
| Low Throughput Method: | Luciferase reporter assay; dCas9-KRAB CRISPRi; siKLF5; RT-qPCR; Western blot; cell-fitness assay |
About Target Gene
| Target gene : | CCNE1 |
About TF
| TF name : | KLF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00874 | chr19:29844909-29845562 | esophagus | malignant cell | esophageal adenocarcinoma |
Expression of Target Genes for the Enhancer