About Enhancer
| Enhancer ID: | E_00851 |
| Species: | Homo sapiens |
| Position : | chr15:45737631-45738460   |
| Year: | 2023 |
| Title: | Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 37370109 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | CFPAC-1 |
| CVCL ID: | CVCL_1119 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Candidate enhancer state annotation within PDAC cell-line panel; Enhancer activity assay; Endogenous enhancer perturbation; Chromatin interaction assay; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq/RNA-seq integration; RNA-seq; CUT&RUN |
| Low Throughput Method: | H3K27ac ChIP-qPCR; RT-qPCR; CRISPRi; Luciferase reporter assay; ChIP; 3C; Western blot; In vivo phenotyping; Xenograft/xenotransplant |
About Target Gene
| Target gene : | GATM |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer