About Enhancer
| Enhancer ID: | E_00841 |
| Species: | Homo sapiens |
| Position : | chr3:148898000-148901500   |
| Year: | 2019 |
| Title: | PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | clear cell renal carcinoma |
| PMID: | 31431624 |
| MONDO: | MONDO:0005005 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Caki-1 |
| CVCL ID: | CVCL_0234 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; ATAC-seq, 3C-seq |
| Low Throughput Method: | ChIP-qPCR; CRISPR Knockout; CRISPRi; Luciferase Reporter Assay, qRT-PCR; Western blot |
About Target Gene
| Target gene : | CP |
About TF
| TF name : | PAX8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX8 | ID | netpath | 38 |
| PAX8 | Pathways in cancer | kegg | 321 |
| PAX8 | Thyroid cancer | kegg | 25 |
| PAX8 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer