About Enhancer
| Enhancer ID: | E_00836 |
| Species: | Homo sapiens |
| Position : | chr8:128264000-128277000   |
| Year: | 2024 |
| Title: | Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | plasma cell myeloma |
| PMID: | 39312195 |
| MONDO: | MONDO:0009693 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | ANBL-6 |
| CVCL ID: | CVCL_5425 |
| Cell Type: | plasma cell |
| Cell Ontology ID: | CL:0000786 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | Pooled CRISPRi tiling screen; H3K27ac ChIP-seq; IRF4 ChIP-seq; Micro-C |
| Low Throughput Method: | Individual CRISPRi; CRISPR-Cas9 IRF4-binding-site mutagenesis; Dual-luciferase reporter assay; qRT-PCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | IRF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| IRF4 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| IRF4 | IL4-mediated signaling events | pid | 66 |
| IRF4 | Interferon alpha/beta signaling | reactome | 67 |
| IRF4 | Interferon gamma signaling | reactome | 88 |
| IRF4 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer