About Enhancer
| Enhancer ID: | E_00803 |
| Species: | Homo sapiens |
| Position : | chr8:128048231-128050347   |
| Year: | 2016 |
| Title: | Systematic mapping of functional enhancer-promoter connections with CRISPR interference. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27708057 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Genome-scale enhancer-target functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | pooled dCas9-KRAB CRISPRi tiling screen; chromatin-accessibility and TF-occupancy integration |
| Low Throughput Method: | single-guide CRISPRi; luciferase reporter; genomic enhancer deletion; qRT-PCR; allele-specific expression validation; CRISPRi |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer