About Enhancer
| Enhancer ID: | E_00796 |
| Species: | Homo sapiens |
| Position : | chr20:44426134-44428433   |
| Year: | 2011 |
| Title: | Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | castration-resistant prostate cancer |
| PMID: | 21556051 |
| MONDO: | MONDO:0008315 |
| Tissue: | bone tissue |
| Tissue Ontology ID: | UBERON:0002481 |
| Cell Source: | PC-3 |
| CVCL ID: | CVCL_0035 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Histone modification assay |
| Low Throughput Method: | 3C-qPCR; luciferase reporter assay; POU2F1 ChIP-qPCR; H3K4me1/H3K4me2 ChIP-qPCR |
About Target Gene
| Target gene : | UBE2C |
About TF
| TF name : | POU2F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU2F1 | AndrogenReceptor | netpath | 167 |
| POU2F1 | ATF-2 transcription factor network | pid | 59 |
| POU2F1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| POU2F1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| POU2F1 | FOXA1 transcription factor network | pid | 45 |
| POU2F1 | Glucocorticoid receptor regulatory network | pid | 85 |
| POU2F1 | Regulation of Androgen receptor activity | pid | 54 |
| POU2F1 | RNA polymerase II transcribes snRNA genes | reactome | 70 |
| POU2F1 | RNA Polymerase III Abortive And Retractive Initiation | reactome | 41 |
| POU2F1 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | reactome | 28 |
| POU2F1 | Hs_Integrated_Cancer_Pathway_WP1971_82939 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00831 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00832 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00833 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00834 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00758 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00794 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00795 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
Expression of Target Genes for the Enhancer