About Enhancer
| Enhancer ID: | E_00795 |
| Species: | Homo sapiens |
| Position : | chr20:44426134-44428433   |
| Year: | 2011 |
| Title: | Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | castration-resistant prostate cancer |
| PMID: | 21556051 |
| MONDO: | MONDO:0008315 |
| Tissue: | bone tissue |
| Tissue Ontology ID: | UBERON:0002481 |
| Cell Source: | PC-3 |
| CVCL ID: | CVCL_0035 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Histone modification assay |
| Low Throughput Method: | 3C-qPCR; luciferase reporter assay; GATA2 ChIP-qPCR; H3K4me1/H3K4me2 ChIP-qPCR |
About Target Gene
| Target gene : | UBE2C |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00831 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00832 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00833 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00834 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00758 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00794 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00796 | chr20:44426134-44428433 | bone tissue | malignant cell | castration-resistant prostate cancer |
Expression of Target Genes for the Enhancer