About Enhancer
| Enhancer ID: | E_00764 |
| Species: | Homo sapiens |
| Position : | chr8:129581780-129583797   |
| Year: | 2016 |
| Title: | Systematic mapping of functional enhancer-promoter connections with CRISPR interference. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27708057 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; functional perturbation assay; chromatin interaction assay; Endogenous enhancer perturbation |
| High Throughput Method: | CRISPRi tiling screen; DNase-seq data integration; H3K27ac ChIP-seq data integration; in situ Hi-C data integration; ChIA-PET data integration |
| Low Throughput Method: | Individual dCas9-KRAB CRISPRi; RT-qPCR; plasmid-based reporter assay; competitive growth assay; CRISPRi |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
47 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03876 | chr8:126650000-129950000 | colon | malignant cell | NA |
| E_02303 | chr8:129440000-129740000 | kidney | malignant cell | rhabdoid tumor |
| E_00804 | chr8:129581780-129583797 | blood | malignant cell | NA |
| E_00057 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00058 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00059 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00060 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00061 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00062 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00161 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00162 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00163 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00164 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00165 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00166 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00167 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00168 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00169 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00170 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00171 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00172 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00173 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00174 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00175 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00176 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00177 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00178 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00179 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00180 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00181 | chr8:129582024-129582425 | bone marrow | malignant cell | acute myeloid leukemia with t(3; 8)(q26; q24) MECOM rearrangement |
| E_00182 | chr8:129582024-129582425 | blood | malignant cell | acute myeloid leukemia |
| E_00183 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00184 | chr8:129582024-129582425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00247 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00248 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00249 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00250 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00251 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00252 | chr8:129582024-129582425 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
| E_00398 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00399 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00427 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00428 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00429 | chr8:129582024-129582425 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00430 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00431 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_00432 | chr8:129582024-129582425 | blood | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer