About Enhancer
| Enhancer ID: | E_00757 |
| Species: | Homo sapiens |
| Position : | chr20:44420684-44421883   |
| Year: | 2011 |
| Title: | Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | castration-resistant prostate cancer |
| PMID: | 21556051 |
| MONDO: | MONDO:0008315 |
| Tissue: | bone tissue |
| Tissue Ontology ID: | UBERON:0002481 |
| Cell Source: | PC-3 |
| CVCL ID: | CVCL_0035 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Histone modification assay; Functional perturbation assay |
| Low Throughput Method: | 3C-qPCR; luciferase reporter assay; FOXA1 ChIP-qPCR; H3K4me1/H3K4me2 ChIP-qPCR; FOXA1 siRNA; MED1 siRNA; RT-qPCR; Western blot |
About Target Gene
| Target gene : | UBE2C |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00831 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00832 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00833 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00834 | chr20:44413081-44426646 | prostate gland | malignant cell | prostate cancer |
| E_00791 | chr20:44420684-44421883 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00792 | chr20:44420684-44421883 | bone tissue | malignant cell | castration-resistant prostate cancer |
| E_00793 | chr20:44420684-44421883 | bone tissue | malignant cell | castration-resistant prostate cancer |
Expression of Target Genes for the Enhancer