About Enhancer
| Enhancer ID: | E_00756 |
| Species: | Homo sapiens |
| Position : | chrX:48782664-48783392   |
| Year: | 2016 |
| Title: | Systematic mapping of functional enhancer-promoter connections with CRISPR interference. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27708057 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | CRISPRi tiling screen; DNase-seq data integration; H3K27ac ChIP-seq data integration; GATA1 ChIP-seq data integration; in situ Hi-C data integration |
| Low Throughput Method: | Individual dCas9-KRAB CRISPRi; RT-qPCR; plasmid-based reporter assay; competitive growth assay; CRISPRi |
About Target Gene
| Target gene : | HDAC6 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00755 | chrX:48782664-48783392 | blood | malignant cell | NA |
Expression of Target Genes for the Enhancer