About Enhancer
| Enhancer ID: | E_00732 |
| Species: | Homo sapiens |
| Position : | chr1:47669000-47669500   |
| Year: | 2014 |
| Title: | Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25394790 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat and TAL1-mutant primary T-ALL |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Neo-enhancer TF-complex occupancy |
| High Throughput Method: | H3K27ac ChIP-seq; TF ChIP-seq |
| Low Throughput Method: | Reporter assay; mutation analysis |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00731 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00733 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00734 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer