About Enhancer
| Enhancer ID: | E_00731 |
| Species: | Homo sapiens |
| Position : | chr1:47669000-47669500   |
| Year: | 2014 |
| Title: | Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25394790 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat and TAL1-mutant primary T-ALL |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Mutation-created neo-enhancer and TF recruitment |
| High Throughput Method: | H3K27ac ChIP-seq; TF ChIP-seq |
| Low Throughput Method: | Reporter assay; mutation analysis; allele-specific enhancer assay |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00732 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00733 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00734 | chr1:47669000-47669500 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer