About Enhancer
| Enhancer ID: | E_00721 |
| Species: | Homo sapiens |
| Position : | chr1:47704954-47704983   |
| Year: | 2014 |
| Title: | Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 25394790 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Mutation-created oncogenic enhancer; TF recruitment; endogenous allele dependency |
| High Throughput Method: | H3K27ac ChIP-seq; MYB/RUNX1/GATA3/TAL1/TCF12 ChIP-seq; RNA polymerase II and MED1 profiling; mutation sequencing |
| Low Throughput Method: | Luciferase reporter assay using 400-bp enhancer fragments; co-immunoprecipitation; allele-specific CRISPR-Cas9 deletion; qRT-PCR; immunoblotting |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
16 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02300 | chr1:47679000-47722000 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_04003 | chr1:47704791-47705107 | blood / hematopoietic system | malignant cell | Central Nervous System Leukemia |
| E_00713 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00715 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00716 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00717 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00718 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00719 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00720 | chr1:47704954-47704983 | blood | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00722 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00723 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00724 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00725 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00726 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00727 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_00728 | chr1:47704954-47704983 | blood | T cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer