About Enhancer
| Enhancer ID: | E_00644 |
| Species: | Homo sapiens |
| Position : | chr11:8240851-8242851   |
| Year: | 2017 |
| Title: | APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 28260788 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | T-acute lymphoblastic leukemia (T-ALL),RPMI-8402 and Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Genetic-variant functional analysis |
| High Throughput Method: | ChIP-seq; ChIA-PET |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | LMO1 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer