About Enhancer
| Enhancer ID: | E_00491 |
| Species: | Homo sapiens |
| Position : | chr7:128573817-128574098   |
| Year: | 2023 |
| Title: | An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 36869052 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | HEK293 |
| CVCL ID: | CVCL_0045 |
| Cell Type: | embryonic kidney cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq; ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay; EMSA; ChIP-RT-qPCR, 3C assay, 4C assay; RT-RT-qPCR |
About Target Gene
| Target gene : | IRF5 |
About TF
| TF name : | ZBTB3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00012 | chr7:128573081-128574098 | blood | CD14-positive monocyte | autoimmune disease |
| E_00013 | chr7:128573081-128574098 | blood | CD14-positive monocyte / macrophage | autoimmune disease |
| E_00024 | chr7:128573081-128574098 | blood | monocyte | autoimmune disease |
| E_00027 | chr7:128573081-128574098 | blood | CD14-positive monocyte / macrophage | autoimmune disease |
| E_00025 | chr7:128573817-128574098 | blood | monocyte | autoimmune disease |
| E_00396 | chr7:128573817-128574098 | blood | CD14-positive monocyte | autoimmune disease |
Expression of Target Genes for the Enhancer