About Enhancer
| Enhancer ID: | E_00459 |
| Species: | Homo sapiens |
| Position : | chr8:128821500-128822500   |
| Year: | 2018 |
| Title: | Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 29731168 |
| MONDO: | MONDO:0004989 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 and breast cancer models |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer-promoter competition/boundary perturbation and chromatin-contact assay |
| High Throughput Method: | H3K27ac HiChIP/chromatin-contact and chromatin-state profiling |
| Low Throughput Method: | CRISPRi/genome editing; UMI-4C/contact validation; MYC/PVT1 nascent RNA and qRT-PCR; CRISPRi |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer