About Enhancer
| Enhancer ID: | E_00455 |
| Species: | Homo sapiens |
| Position : | chr8:130180012-130180748   |
| Year: | 2025 |
| Title: | The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during T cell leukemogenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 41129262 |
| MONDO: | MONDO:0004963 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | THP-6 |
| CVCL ID: | CVCL_4686 |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer essentiality screen; TF binding assay; Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | Genome-wide CRISPRi screen; ETS1 ChIP-seq; H3K27ac ChIP-seq; ATAC-seq; pooled CRISPRi screen |
| Low Throughput Method: | CRISPRi |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | ETS1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ETS1 | Angiogenesis | panther | 141 |
| ETS1 | Angiopoietin receptor Tie2-mediated signaling | pid | 50 |
| ETS1 | AP-1 transcription factor network | pid | 71 |
| ETS1 | BCR signaling pathway | pid | 70 |
| ETS1 | C-MYB transcription factor network | pid | 87 |
| ETS1 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ETS1 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ETS1 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ETS1 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ETS1 | HIF-1-alpha transcription factor network | pid | 67 |
| ETS1 | HIF-2-alpha transcription factor network | pid | 34 |
| ETS1 | IL2 | netpath | 81 |
| ETS1 | IL4-mediated signaling events | pid | 66 |
| ETS1 | IL4 | netpath | 75 |
| ETS1 | Oncogene Induced Senescence | reactome | 30 |
| ETS1 | PDGF signaling pathway | panther | 113 |
| ETS1 | Ras Pathway | panther | 69 |
| ETS1 | Signaling events mediated by focal adhesion kinase | pid | 63 |
| ETS1 | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | pid | 80 |
| ETS1 | TGF_beta_Receptor | netpath | 220 |
| ETS1 | VEGF signaling pathway | panther | 54 |
| ETS1 | MAPK signaling pathway - fly | kegg | 16 |
| ETS1 | Dorso-ventral axis formation | kegg | 25 |
| ETS1 | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| ETS1 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| ETS1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| ETS1 | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
| ETS1 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
67 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02010 | chr8:130179643-130181490 | blood / hematopoietic system | T cell | T-cell acute lymphoblastic leukemia |
| E_01422 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01423 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01424 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01425 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01426 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01427 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01428 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01429 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01435 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01436 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01437 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01438 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01980 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01981 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01982 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01983 | chr8:130180065-130180972 | thymus | T-lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01988 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01989 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01990 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01991 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01992 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01993 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01994 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01995 | chr8:130180065-130180972 | thymus | T cell | T-cell acute lymphoblastic leukemia |
| E_01996 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01997 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01998 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_01999 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02000 | chr8:130180065-130180972 | bone marrow | T cell | T-cell acute lymphoblastic leukemia |
| E_02001 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_02002 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02003 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_02007 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02008 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03525 | chr8:130180065-130180972 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03541 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03542 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03545 | chr8:130180065-130180972 | thymus | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03546 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03547 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03548 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03549 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03577 | chr8:130180065-130180972 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_04520 | chr8:130180065-130180972 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04526 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04527 | chr8:130180065-130180972 | bone marrow | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04528 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04529 | chr8:130180065-130180972 | blood | T-lineage lymphoblast/leukemia cell | T-cell acute lymphoblastic leukemia |
| E_01368 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01369 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01414 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01415 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01416 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01417 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01418 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01419 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_01420 | chr8:130180217-130180629 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01421 | chr8:130180217-130180629 | lymph | T cell | T-cell acute lymphoblastic leukemia |
| E_03543 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03544 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03551 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03552 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03553 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_03554 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04512 | chr8:130180217-130180629 | blood | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
| E_04513 | chr8:130180217-130180629 | bone marrow | T-lineage leukemia cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer