About Enhancer
| Enhancer ID: | E_00453 |
| Species: | Homo sapiens |
| Position : | chr1:16160379-16162282   |
| Year: | 2020 |
| Title: | Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hematopoietic malignancy |
| PMID: | 32188707 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MKPL-1 |
| CVCL ID: | CVCL_2116 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | High-throughput functional CRE perturbation screen; candidate enhancer annotation; Disease-variant functional analysis |
| High Throughput Method: | pooled enCRISPRi screen; pooled enCRISPRa screen; H3K27ac ChIP-seq; ATAC-seq |
| Low Throughput Method: | individual CRISPRi; CRISPR-Cas9 TF-binding-site deletion |
About Target Gene
| Target gene : | SPEN-AS1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00452 | chr1:16160379-16162282 | bone marrow | malignant cell | hematopoietic malignancy |
| E_00495 | chr1:16160379-16162282 | bone marrow | malignant cell | hematopoietic malignancy |
| E_00646 | chr1:16160379-16162282 | blood | NA | hematologic malignancy |
| E_02020 | chr1:16162175-16195191 | ovary | malignant cell | ovarian carcinoma |
Expression of Target Genes for the Enhancer