About Enhancer
| Enhancer ID: | E_00425 |
| Species: | Homo sapiens |
| Position : | chr16:53800454-53801454   |
| Year: | 2015 |
| Title: | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 26287746 |
| MONDO: | MONDO:0011122 |
| Tissue: | subcutaneous adipose tissue |
| Tissue Ontology ID: | UBERON:0002190 |
| Cell Source: | primary human subcutaneous adipose progenitors |
| Cell Type: | subcutaneous preadipocyte |
| Cell Ontology ID: | CL:0002583 |
| Experiment Type: | Endogenous enhancer-variant validation; target-gene perturbation; cellular phenotype assay; Enhancer activity assay; Endogenous enhancer perturbation; Disease-variant functional analysis |
| High Throughput Method: | eQTL/trans-eQTL analysis; gene-expression profiling |
| Low Throughput Method: | CRISPR-Cas9 bidirectional single-nucleotide editing; IRX3 knockdown/overexpression; RT-qPCR; oxygen-consumption and thermogenesis assays; CRISPR-Cas9 endogenous deletion/editing; Allele-specific reporter assay |
About Target Gene
| Target gene : | IRX3 |
About TF
| TF name : | ARID5B |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ARID5B | HDMs demethylate histones | reactome | 49 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
Expression of Target Genes for the Enhancer