About Enhancer
| Enhancer ID: | E_00422 |
| Species: | Homo sapiens |
| Position : | chr6:156425000-156525000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 6) AML blasts |
| Cell Type: | myeloid leukemia blast cell |
| Cell Ontology ID: | CL:0000947 |
| Experiment Type: | Chromatin architectural element / enhancer-docking analysis |
| High Throughput Method: | Structural-variant mapping; H3K27ac ChIP-seq; hematopoietic TF/CTCF ChIP-seq; RNA-seq |
| Low Throughput Method: | FISH; breakpoint PCR; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00394 | chr6:156425000-156525000 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00395 | chr6:156425000-156525000 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00423 | chr6:156425000-156525000 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00450 | chr6:156425000-156525000 | blood | CD34-positive hematopoietic stem/progenitor cell | NA |
Expression of Target Genes for the Enhancer