About Enhancer
| Enhancer ID: | E_00418 |
| Species: | Homo sapiens |
| Position : | chr3:128603426-128604425   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 34584081 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary human CD34+ hematopoietic stem/progenitor cells |
| Cell Type: | CD34-positive hematopoietic stem/progenitor cell |
| Experiment Type: | Native enhancer TF-binding/chromatin-state validation |
| High Throughput Method: | H3K27ac ChIP-seq; hematopoietic TF ChIP-seq; structural-variant mapping; RNA-seq |
| Low Throughput Method: | Targeted ChIP validation; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | GATA2 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00340 | chr3:128603426-128604425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_00392 | chr3:128603426-128604425 | bone marrow | myeloid leukemia blast cell | acute myeloid leukemia |
| E_03951 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| E_03979 | chr3:128603821-128604120 | bone marrow | myeloid leukemia cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
| E_04324 | chr3:128603821-128604120 | bone marrow | hematopoietic stem/progenitor cell | acute myeloid leukemia with inv(3)(q21.3q26.2)/t(3;3)(q21.3;q26.2) |
Expression of Target Genes for the Enhancer