About Enhancer
| Enhancer ID: | E_00393 |
| Species: | Homo sapiens |
| Position : | chr7:92755125-92755526   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 7) AML blasts |
| Cell Type: | myeloid leukemia blast cell |
| Cell Ontology ID: | CL:0000947 |
| Experiment Type: | Candidate enhancer hijacking; TF binding; chromatin-state validation |
| High Throughput Method: | Structural-variant mapping; H3K27ac ChIP-seq; hematopoietic TF ChIP-seq; RNA-seq |
| Low Throughput Method: | FISH; breakpoint PCR; RT-qPCR; CRISPR-Cas9 |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer